MCQ on Purine and Pyrimidine Metabolism




Purine and Pyrimidine metabolism are essential biochemical pathways responsible for the synthesis and degradation of purine and pyrimidine nucleotides. Purines (like adenine and guanine) and pyrimidines (like cytosine, thymine, and uracil) are the buildin blocks of DNA and RNA. These pathways ensure the balanced production and utilization of these nucleotides, preventing the accumulation of toxic byproducts and maintaining cellular functions. This is an MCQ on Purine and Pyrimidine Metabolism.

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1. 
What is the primary function of purine and pyrimidine metabolism in the body?

2. 
Which of the following is a purine base?

3. 
In purine metabolism, what is the immediate precursor of uric acid?

4. 
Which enzyme is responsible for converting hypoxanthine to xanthine in the purine catabolic pathway?

5. 
What genetic disorder results from a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and leads to the accumulation of uric acid?

6. 
Which enzyme is responsible for the conversion of orotate to UMP (uridine monophosphate) in pyrimidine metabolism?

7. 
In pyrimidine metabolism, which enzyme converts dihydroorotate to orotate?

8. 
Which of the following is not a pyrimidine base found in nucleic acids?

9. 
In purine metabolism, what is the end product of the degradation of guanine?

10. 
Which enzyme plays a critical role in converting ribonucleotides to deoxyribonucleotides in both purine and pyrimidine metabolism?

11. 
What is the primary function of the enzyme adenosine deaminase (ADA) in purine metabolism?

12. 
In pyrimidine metabolism, which enzyme is responsible for the conversion of CTP to dCTP, an essential precursor for DNA synthesis?

13. 
Which genetic disorder is associated with the accumulation of orotic acid due to a deficiency of the enzyme involved in the conversion of orotate to UMP?

14. 
What is the primary role of orotate in pyrimidine metabolism?

15. 
Both purine and pyrimidine nucleotides are essential components of which biological molecules?

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