MCQ on Pyrimidine Synthesis




Pyrimidine synthesis is a biochemical pathway to produce pyrimidine nucleotides, which are key components of DNA, RNA, and molecules like ATP and UTP. It involves a series of enzymatic reactions that convert precursor molecules into pyrimidines, such as cytosine, thymine, and uracil, essential for genetic and metabolic processes. This is an MCQ on Pyrimidine Synthesis and its significance.

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Learn more: Simplified Note on Pyrimidine Biosynthesis

1. 
Pyrimidines are a class of nitrogenous bases that are essential components of:

2. 
The two major pyrimidine bases found in DNA and RNA are:

3. 
In the biosynthesis of pyrimidines, carbamoyl phosphate is formed from the condensation of:

4. 
The committed step in the de novo synthesis of pyrimidines involves the formation of:

5. 
The enzyme dihydroorotase converts dihydroorotate to:

6. 
The enzyme orotate phosphoribosyltransferase catalyzes the conversion of orotate to:

7. 
Orotidine-5'-monophosphate (OMP) is decarboxylated by the enzyme orotidylate decarboxylase to form:

8. 
In the pyrimidine salvage pathway, uracil can be converted back to UMP by the enzyme:

9. 
The enzyme thymidylate synthase is essential for the conversion of:

10. 
The end product of the de novo synthesis of pyrimidines is:

11. 
Which of the following drugs is an antimetabolite that inhibits the enzyme dihydrofolate reductase and interferes with pyrimidine synthesis?

12. 
Pyrimidine bases can be salvaged from:

13. 
The enzyme cytidine deaminase converts cytidine to:

14. 
Pyrimidine synthesis is regulated by the feedback inhibition of:

15. 
The overall purpose of pyrimidine synthesis is to provide the cell with:

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