MCQ on Homology Modelling of Proteins




Homology modelling, also known as comparative modelling, is a computational technique in structural biology. It predicts the 3D structure of a protein based on the known structure of a related protein (homolog). It relies on the assumption that structurally similar proteins share similar functions. This is an MCQ on Homology Modelling for your understanding.

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1. 
Homology modeling is a computational technique used to predict the three-dimensional structure of a protein based on:

2. 
The primary template for homology modeling is a protein with a known three-dimensional structure. What is this template commonly referred to as?

3. 
The level of sequence identity between the target protein (to be modeled) and the template protein significantly affects the accuracy of homology modeling. Generally, a sequence identity of ______ or higher is required for reliable homology modeling.

4. 
The alignment of the target protein sequence with the template sequence is a critical step in homology modeling. Which parameter measures the quality of this alignment?

5. 
Homology modeling relies on the assumption that proteins with similar sequences share:

6. 
The modeling process involves building a 3D model of the target protein using spatial restraints derived from the:

7. 
Which software tools are commonly used for homology modeling?

8. 
In homology modeling, what do we call the regions in the model where there is no corresponding template information?

9. 
What is the name of the statistical potential used to evaluate the energy and stereochemistry of the protein model in homology modeling?

10. 
The quality of a homology model can be assessed using various validation tools. Which tool helps assess the local quality of the model's backbone and side-chain dihedral angles?

11. 
Homology modeling is especially useful when experimental techniques like X-ray crystallography or NMR are challenging to apply due to:

12. 
In homology modeling, if the sequence identity between the target and template proteins is below the reliable threshold, what alternative approach can be used?

13. 
The accuracy of homology modeling is generally assessed by comparing the predicted model with the experimentally determined structure using:

14. 
Which of the following protein families is particularly well-suited for homology modeling due to the abundance of available templates?

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