Difference between Gas Solid Chromatography and Gas Liquid Chromatography: Comparison Table


Difference between GSC and GLC

Gas-Solid Chromatography (GSC) vs Gas-Liquid Chromatography (GLC)
(Difference between GSC and GLC Chromatography)

Gas Chromatography or GC is a chromatographic technique used for the separation of volatile compounds. In GC, a mixture of volatile compounds with differential migration passes through a column containing solid or liquid stationary phase. In GC, the mixture to be separated should be in gaseous phase and the mobile phase used will be always in the gaseous state (usually an inert gas such as nitrogen, helium or argon). Based on the states of stationary phases, there are two types of Gas Chromatography techniques: (1) Gas Solid Chromatography (GSC) and (2) Gas Liquid Chromatography (GLC).

(1). Gas Solid Chromatography (GSC): In GSC, the stationary phase is in the solid state (liquid phase is absent). The stationary phase is coated in the interior of the column. Molecules in the stationary phase will interact with the mobile phase through adsorption forces.

(2). Gas Liquid Chromatography (GLC): In GLC, the stationary phase is a nonvolatile liquid. The liquid stationary phase is coated on an inert support in the column. The mobile phase will be an inert gas such as nitrogen, helium or argon.

There are considerable differences in the working principle, mobile and stationary phase and the efficiency of GSC and GLC. The present post discusses the similarities and differences between Gas Solid Chromatography (GSC) and Gas Liquid Chromatography (GLC) with a comparison table.

Similarities between Gas Liquid and Gas Solid Chromatography

Ø  Both are GSC and GLC are Gas chromatographic techniques.

Ø  Both uses gaseous mobile phase (usually an inert gas such as N, He etc.).

Ø  Both are used for the separation of volatile compounds / mixtures.

Ø  Heat labile compounds cannot be separated.

Ø  Both GSC and GLC can be analytic or preparatory.

Ø  Both types of GC use similar type of detectors.

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