Molecular Biology Tutorials

Single Stranded DNA (ssDNA) vs Double Stranded DNA (dsDNA): Similarities and Differences

single stranded and double stranded DNA

ssDNA vs dsDNA – A Comparison Table

The DNA molecules are not always double stranded helical structures, sometimes they occur in single stranded form called ssDNA. In 1959 Robert Sinsheimer discovered a unique bacteriophage called φX 174 (which infect Escherichia coli) with single stranded DNA as its genetic material. Even though the chemical composition of single stranded and double stranded DNA are the same, they also show some characteristic differences. The present post describes the similarities and differences between dsDNA and ssDNA.s

Similarities between dsDNA and ssDNA

Ø  Both dsDNA and ssDNA can acts as genetic material

Ø  Both are polymers of nucleic acids

Ø  The sugar molecule in both the case is deoxyribose

Ø  Both contain purines and pyramidines

Ø  Both ssDNA and dsDNA contain the nitrogen bases A, G, T and C

Ø  Both can absorb UV light

Difference between dsDNA vs  ssDNA

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