Difference between Osteoblast and Osteoclast: Comparison Table

Compare Osteoblast and Osteoclast

Osteoblast vs Osteoclast
(Similarities and Differences between Osteoblast and Osteoclast)

Osteoblasts and Osteoclasts are the two types of bone cells which constitute the bone tissue or the osseous tissue. The bone is a metabolically active tissue consisting of several types of cells among which the Osteoblasts and Osteoclasts are the most important ones. Osteoblasts are responsible for the formation of bone whereas the osteoclasts are responsible for the breakdown of the bones. The coordinated actions of these two cells are required for the formation and resorption (breakdown) of bones. This coordinated action between osteoblasts and osteoclasts is known as Bone Remodeling. Bone remodeling also ensures the maintenance of bones and the regulation of mineral levels, particularly calcium and phosphorous, in the body.

Similarities between Osteoblasts and Osteoclasts

Ø  Both osteoblasts and osteoclasts are bone cells.

Ø  Both are involved in bone remodeling.

Ø  Both are involved in the repair of bones.

Ø  Both are living cells with nucleus.

Ø  Both are metabolically very active cells.

Ø  Both cells are located on the surface of osteon seam.

Ø  Both are connective tissues.

Bone Remodeling

image source: wikipedia

Difference between Osteoblasts and Osteoclasts

Sl. No.OsteoblastsOsteoclasts
1Osteoblasts assist in the formation of bone.Osteoclasts assist in the breakdown of bones.
2Cells are comparatively smaller.Cells are comparatively large.
3Osteoblasts are uninucleate.Osteoclasts are multinucleate.
4The cells possess comparatively lesser number of mitochondria, vacuoles and lysosomes.The cells possess comparatively large number of mitochondria, vacuoles and lysosomes.
5Cells make the protein- osteoid.Do not make the osteoid protein.
6Cells do not possess sealing zones and ruffled borders.Cells possess sealing zones and ruffled borders.
7Osteocytes produce a hormone- Prostaglandins.Osteoblasts do not produce any hormones.
8Cells possess parathyroid (PTH) hormone receptors.Parathyroid hormone receptors are absent in osteoclasts.
9Cells produce large amount of alkaline phosphatase enzyme.Cells produce large amount of tartrate resistant acid phosphatase enzyme.
10Osteoblasts are derived from pluripotent mesenchymal stem cells.Osteoclasts are derived from hematopoietic cells of granulocyte- macrophage lineage.
11Osteoblasts are not equipped with phagocytic-like mechanism.Osteoclasts are equipped with phagocytic-like mechanism.
12Osteoblasts become osteocytes at the end of the bone formation.Osteoclasts do not become osteocytes.

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