KERALA UNIVERSITY Ph.D. ENTRANCE EXAMINATION
FACULTY OF APPLIED SCIENCES
COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
Time: 140 Minutes Maximum Marks: 160
Note: Answer any twelve questions from Section B and one question from Section C in the subject concerned. In Section B, each question carries 10 marks. Section C carries 40 marks. In Section B an answer should not exceed 100 words. In Section C, an answer should not exceed 500 words.
SECTION – B
(1). Explain the terms:
a. Sequence Similarity and Sequence Identity
b. E-value in BLAST
(2). Align the following sequence using dynamic programming for Global alignment: ATTGC and AGGC
(3). Compare the following sequence alignment tools:
(4). What is meant by Consensus sequences in Bioinformatics? Compare Sequence logo and Consensus logo.
(5). Explain the Multiple Sequence Alignment algorithm of ClustalW.