Molecular Biology Tutorials

Cell Cycle Checkpoints in Regulation of Cell Division and Cancer


Cell Cycle Checkpoints and Cancer

Cell Cycle Checkpoints and Regulation of Cell Cycle

What is cell cycle checkpoint?

Every cell in our body pass through a series of different stages in a cyclic manner called cell cycle.  Cell cycle is a sequential step that taking place in a cell leading to the accurate duplication of genetic materials (DNA), precise separation of replicated genetic materials and passing them in to two daughter cells.  The process of cell cycle is very critical in each cell, thus it operate strictly under strong surveillance to prevent any mistakes. This strong surveillance system in the cell to monitor the cell cycle progression itself is called cell cycle checkpoints. Checkpoints are surveillance mechanisms that halt the progress of cell cycle if (1) any of the chromosomal DNA is damaged, or (2) critical cellular processes, such as DNA replication during S phase or chromosome alignment during M phase, have not been properly completed. Thus cell cycle checkpoints ensure that the various events in the cell cycle progression occur accurately and in correct order. In this post we will discuss the three types of cell cycle checkpoints that operate in eukaryotic cells during cell cycle progression.

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